abstract：:During alpaca testis development and spermatogenesis, nerve growth factor (NGF) may play an important role. The main aim of this study was to determine the expression and localization of NGF in the alpaca testis, and to discuss the important role of NGF in alpaca reproductive characteristics. Immunohistochemical stain...

journal_title：Folia histochemica et cytobiologica

authors： Wang H,Dong Y,Chen W,Hei J,Dong C

更新日期：2011-01-01 00:00:00

abstract：:Primary lung cancer remains the leading cause of cancer death worldwide. Promoter hypermethylation is a major inactivation mechanism of tumor-related genes, and increasingly appears to play an important role in carcinogenesis. In the present study, we used quantitative methylation-specific PCR (Q-MSP) assays to analyz...

journal_title：Folia histochemica et cytobiologica

authors： Ji M,Guan H,Shi B,Hou P

更新日期：2011-01-01 00:00:00

abstract：:The increased ambient temperature affects the function of hypothalamic-pituitary-adrenal (HPA) axis. Since the correlation among vasopressin (VP), adrenocorticotropic hormone (ACTH) and corticosterone (CORT) responses to various stressors have been long recognized, the aim of this study was to reveal the aforementione...

journal_title：Folia histochemica et cytobiologica

authors： Jasnic N,Korac A,Velickovic K,Golic I,Djordjevic J,Djurasevic S,Djordjevic I,Vujovic P,Cvijic G

更新日期：2010-12-01 00:00:00

abstract：:The fibroblast growth factors (FGFs) are multifunctional proteins that, among other roles, regulate structural reorganization of uterine and placental vascular bed during pregnancy. Thus, we analyzed mRNA and protein expression and immunohistochemical localization of FGF-1 and FGF-2, and their receptors (FGFR-1 and FG...

journal_title：Folia histochemica et cytobiologica

authors： Chrusciel M,Rekawiecki R,Ziecik AJ,Andronowska A

更新日期：2010-12-01 00:00:00

abstract：:The study aimed at examination of tissue expression of polysaccharides and secretory mucin 5AC (MUC5AC) in young patients (up to 25 years of age) with a symptomatic gallstones. For comparison, patients most frequently subjected to cholecystectomy were studied, i.e. patients of approximately 50 years of age with the sa...

journal_title：Folia histochemica et cytobiologica

authors： Kasprzak A,Malkowski W,Helak-Łapaj C,Seraszek A,Kaczmarek E,Adamek A,Zabel M

更新日期：2010-12-01 00:00:00

abstract：:Preterm labour and prematurity are still a main cause of perinatal morbidity nowadays. The aim of our study was to assess the role of MMP-8 as a predictive marker of preterm delivery. Four groups of patients were involved to the study: I - pregnant women at 24-34 weeks of gestation with any symptoms of threatened pret...

journal_title：Folia histochemica et cytobiologica

authors： Kuć P,Lemancewicz A,Laudański P,Krętowska M,Laudański T

更新日期：2010-09-30 00:00:00

abstract：:The recurrent goiter is the regrowth of thyroid tissue after thyroidectomy. An inadequate surgical removal of the thyroid gland, lack of substitution therapy and pathological stimulation of the thyroid growth can all promote the recurrence. The aim of this study was to find the connection between the histopathological...

journal_title：Folia histochemica et cytobiologica

authors： Rudnicki J,Agrawal AK,Jelen M,Sebastian M,Sroczyński M,Zyśko D

更新日期：2010-09-30 00:00:00

abstract：:To date four types of glial cells have been identified in central nervous system: astrocytes, oligodendrocytes, microglia, ependymocytes. The latest results indicate the existence of the fifth glial type-synantocytes from the Greek word synanto that is for contact. Synantocyte processes reach neurons, astrocytes, olig...

journal_title：Folia histochemica et cytobiologica

authors： Krawczyk A,Jaworska-Adamu J

更新日期：2010-01-01 00:00:00

abstract：:The aim of this study was to estimate distant results after discontinuation of long term lamivudine treatment in children with chronic hepatitis B. Furthermore, the emergence of HBV polymerase gene variants in YMDD motif during therapy was examined. Additionally, the most commonly occurring type of mutation in the pol...

journal_title：Folia histochemica et cytobiologica

authors： Pancewicz J,Kowalczuk O,Chyczewski L

更新日期：2010-01-01 00:00:00

abstract：:The current study was inspired by the fact that since 2004 no report had appeared on the occurrence of this peptide in healthy parotid glands of humans and animals. The objective of the current study was to investigate the immunolocalization of PTHrP in the parotid gland of three male rodents: 6 common voles (Microtus...

journal_title：Folia histochemica et cytobiologica

authors： Czykier E,Zabel M,Seidel J

更新日期：2010-01-01 00:00:00

abstract：:Using morphological criteria we describe the effect of maternal deprivation on the gonadotrophin-releasing hormone (GnRH) and GnRH-associated peptide (GAP) of the GnRH prohormone (proGnRH) in the preoptic area (POA)-hypothalamus during the weaning period. The immunohistochemical GnRH- and GAP-neuroanatomy was investig...

journal_title：Folia histochemica et cytobiologica

authors： Wańkowska M,Polkowska J

更新日期：2010-01-01 00:00:00

abstract：:The aim of the study was to evaluate the prognostic value of the vascular endothelial growth factor A (VEGF-A) and hepatocyte growth factor receptor (HGFR, c-met) expressions in homogenous group of breast cancer patients. Tumor samples were collected from 98 patients with invasive ductal breast carcinoma stage II trea...

journal_title：Folia histochemica et cytobiologica

authors： Gisterek I,Matkowski R,Suder E,Hałoń A,Szelachowska J,Łata E,Łacko A,Biecek P,Kornafel J

更新日期：2010-01-01 00:00:00

abstract：:The effectiveness of the long acting somatostatin analogues like octreotide and lanreotide depends on the expression of specific somatostatin receptors on the target cells. The immunohistochemical method performed on surgically removed tumors searches the expression of receptors at the level of receptor protein and gi...

journal_title：Folia histochemica et cytobiologica

authors： Pisarek H,Pawlikowski M,Kunert-Radek J,Kubiak R,Winczyk K

更新日期：2010-01-01 00:00:00

abstract：:Forty pituitary adenomas were immunostained with an antibody raised against the C-terminal fragment (101-109) of human prothymosin alpha (PT alpha). The strong positive immunostaining was found in the subpopulation of cell nuclei and intratumoral vessel walls, while the cytoplasm of adenoma cells was slightly immunopo...

journal_title：Folia histochemica et cytobiologica

authors： Pawlikowski M,Winczyk K

更新日期：2009-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common cancers of the gastrointestinal tract and the fourth cause of cancers death in the world. Soluble adhesion molecules (CAMs) are thought to have an important role in host defense against carcinogenesis. They are biomarkers of inflammation and indicators of the immune re...

journal_title：Folia histochemica et cytobiologica

authors： Mantur M,Snarska J,Koper O,Dziecioł J,Płonski A,Lemancewicz D

更新日期：2009-01-01 00:00:00

abstract：:Grid technology has enabled the clustering and the efficient and secure access to and interaction among a wide variety of geographically distributed resources such as: supercomputers, storage systems, data sources, instruments and special devices and services. Their main applications include large-scale computational ...

journal_title：Folia histochemica et cytobiologica

authors： Bueno G,Déniz O,Salido J,Rojo MG

更新日期：2009-01-01 00:00:00

abstract：:The aim of this study was to examine the prevalence and clinicopathological significance of KRAS point mutation in endometrial hyperplasia and carcinoma. We analysed KRAS in 11 cases of complex atypical hyperplasia and in 49 endometrial carcinomas using polymerase chain reaction associated with restriction fragment le...

journal_title：Folia histochemica et cytobiologica

authors： Dobrzycka B,Terlikowski SJ,Mazurek A,Kowalczuk O,Niklińska W,Chyczewski L,Kulikowski M

更新日期：2009-01-01 00:00:00

abstract：:Diplotene oocyte nucleus of the scorpionfly Panorpa communis is transcriptionally silent and contains numerous nuclear bodies including interchromatin granule clusters (IGCs). The latter consist of the granules of 30-50 nm in diameter and contain IGC marker protein SC35 as well as RNA polymerase II. In this study, we ...

journal_title：Folia histochemica et cytobiologica

authors： Batalova F,Parfenov V

更新日期：2009-01-01 00:00:00

abstract：:A literature survey was performed of the methods of quantitative assessment of the activity and concentration of cathepsin D and its inhibitors. Usefulness of non-modified and modified proteins and synthetic peptides as measurement substrates was evaluated. The survey includes also chemical and immunochemical methods ...

journal_title：Folia histochemica et cytobiologica

authors： Minarowska A,Karwowska A,Gacko M

更新日期：2009-01-01 00:00:00

abstract：:Exposure to glucocorticoids (GCs) leads to numerous changes in various biological systems including the reproductive system. The aim of the present study was to find out whether dexamethasone (Dex), a widely used GC, would influence the apoptosis and expression of Bax, an important proapoptotic protein, in the mouse t...

journal_title：Folia histochemica et cytobiologica

authors： Mahmoud H,Mahmoud O,Layasadat K,Naeim A

更新日期：2009-01-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is an endocrinological and metabolic disorder which may concern about 3-8% of women. Some PCOS women have the increased leptin concentration in blood serum. Leptin concentration is higher in patients with high body mass index (BMI) and impaired tissue sensitivity to insulin. The aim of...

journal_title：Folia histochemica et cytobiologica

authors： Marciniak A,Nawrocka-Rutkowska J,Brodowska A,Sienkiewicz R,Szydłowska I,Starczewski A

更新日期：2009-01-01 00:00:00

abstract：:The biology of breast cancer is closely releted to sex steroid hormones. Estrogen receptor beta is overexpressed in around 70% breast cancer cases, referrd to as "ER positive". Estrogens bind to estrogen receptor and stimulate the transcription of genes involved in control of cell proliferation. Moreover, estrogens ma...

journal_title：Folia histochemica et cytobiologica

authors： Leśniewska M,Miltyk W,Swiatecka J,Tomaszewska M,Kuźmicki M,Pałka J,Wołczyński S

更新日期：2009-01-01 00:00:00

abstract：:Embryo implantation consists of a series of events promoting the invasion of the endometrium and then the uterine arterial system by the extra-embryonic trophoblast. In order for this semi-heterologous implantation to succeed, the endometrium has to first undergo a number of structural and biochemical changes (decidua...

journal_title：Folia histochemica et cytobiologica

authors： Merviel P,Lourdel E,Cabry R,Boulard V,Brzakowski M,Demailly P,Brasseur F,Copin H,Devaux A

更新日期：2009-01-01 00:00:00

abstract：:Spermatogenesis involves the realization of a particular genetic program which requires a specific environment ("niche"). Multiplication, differentiation and apoptosis of male germ cells are finely regulated by pituitary hormones (mainly LH and FSH), and by a complex network of factors originating from both the somati...

journal_title：Folia histochemica et cytobiologica

authors： Perrard MH,Prisant N,Geoffroy-Siraudin C,Segretain D,Pointis G,Guichaoua MR,Durand P

更新日期：2009-01-01 00:00:00

abstract：:Structural chromosome aberrations and associated segmental or chromosomal aneusomies are major causes of reproductive failure in humans. Despite the fact that carriers of reciprocal balanced translocation often have no other clinical symptoms or disease, impaired chromosome homologue pairing in meiosis and karyokinesi...

journal_title：Folia histochemica et cytobiologica

authors： Lu CM,Kwan J,Weier JF,Baumgartner A,Wang M,Escudero T,Munné S,Weier HU

更新日期：2009-01-01 00:00:00

abstract：:The family of epidermal growth factor (EGF, EGFR, c-erbB-2) plays a pivotal role in gastric cancer progression, invasion and metastasizing. Helicobacter pylori infection is known to contribute significantly to the formation and progression of gastric cancer. However, the mechanisms responsible for this process have no...

journal_title：Folia histochemica et cytobiologica

authors： Pryczynicz A,Guzińska-Ustymowicz K,Kemona A,Czyzewska J

更新日期：2009-01-01 00:00:00

abstract：:Degradation of extracellular matrix (ECM) is an essential step of invasion and metastasis of gastric cancer. The proteolysis of basement membranes depends on the balance between activities of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). The aim of the study was to assess the expression of TIMP...

journal_title：Folia histochemica et cytobiologica

authors： Mroczko B,Lukaszewicz-Zajac M,Groblewska M,Czyzewska J,Gryko M,Guzińska-Ustymowicz K,Kemona A,Kedra B,Szmitkowski M

更新日期：2009-01-01 00:00:00

abstract：:At present, not much is known about progesterone receptor (PR) expression and localization in postmenopausal women ovaries. In the ovaries of reproductive age women, PR is localized in internal theca and granulosa cells, corpus luteum, ovary surface epithelium (OSE) and in stroma. PR expression depends on the serum co...

journal_title：Folia histochemica et cytobiologica

authors： Starczewski A,Brodowska A,Laszczyńska M,Piasecka M

更新日期：2008-01-01 00:00:00

abstract：:Tuberculosis (TB) still remains the leading cause of mortality due to bacterial pathogen. The only currently available vaccine against TB, Bacille Calmette-Guérin (BCG) is at best credited with a 50% overall protective efficacy. Skin testing with purified protein derivative (PPD) from Mycobacterium tuberculosis is the...

journal_title：Folia histochemica et cytobiologica

authors： Strapagiel D,Kasztalska K,Druszczyńska M,Kowalewicz-Kulbat M,Vrba A,Matusiak A,Chmiela M,Rudnicka W

更新日期：2008-01-01 00:00:00

abstract：:A literature survey was performed of human cathepsin D gene, cathepsin D biosynthesis, posttranslatory modifications, transport within the cell, substrate specificity and catalytic effect. Methods used to determine the activity and level of this proteinase as well as its role in the biochemistry and pathobiochemistry ...

journal_title：Folia histochemica et cytobiologica

authors： Minarowska A,Gacko M,Karwowska A,Minarowski Ł

更新日期：2008-01-01 00:00:00

abstract：:Lung cancer is the leading cause of death worldwide. High mortality comes out mainly of the fact that majority of the cases are diagnosed in advanced stadium. An expanded diagnostics of precancerous conditions would certainly contribute to lowering the mortality rate. Many of the molecular changes accompanying the mul...

journal_title：Folia histochemica et cytobiologica

authors： Pankiewicz W,Sulewska A,Niklinska W,Naumnik W,Laudanski J,Niklinski J,Chyczewski L

更新日期：2008-01-01 00:00:00

abstract：:Recently identified biological risk factors in B-cell chronic lymphocytic leukemia (B-CLL) include ZAP-70 and CD38 expression. The present study was conducted to clarify whether a combined analysis could improve predictive impact of these two parameters. We examined the expression of ZAP-70 and CD38 by flow cytometry ...

journal_title：Folia histochemica et cytobiologica

authors： Hus I,Bojarska-Junak A,Dmoszyńska A,Wasik-Szczepanek E,Sieklucka M,Trześniewska W,Glazer M,Roliński J

更新日期：2008-01-01 00:00:00

abstract：:Nitric oxide (NO) is produced by NO synthase (NOS) isoforms: neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible NOS (iNOS). It is believed that, while nNOS and eNOS are effective in regulation of normal physiological processes, iNOS is expressed at an increasing rate especially in inflammatory process. The aim ...

journal_title：Folia histochemica et cytobiologica

authors： Keklikoglu N

更新日期：2008-01-01 00:00:00

abstract：:T cell memory in comparison with B cell memory is not well understood. This review focuses on CD8+ and CD4+ memory T cells. In this article we try to define memory cells and also present models of memory T cells formation. We would also like to delineate their differentiation into distinct subsets. Long-lived memory T...

journal_title：Folia histochemica et cytobiologica

authors： Ojdana D,Safiejko K,Lipska A,Radziwon P,Dadan J,Tryniszewska E

更新日期：2008-01-01 00:00:00

abstract：:Therapeutic outcomes of definitively treated non-small-cell lung cancer (NSCLC) are unacceptably poor. It has been proposed that the manipulation of dendritic cells (DCs) as a "natural" vaccine adjuvant may prove to be a particularly effective way to stimulate antitumor immunity. Presently, there is no standardized me...

journal_title：Folia histochemica et cytobiologica

authors： Jankowska O,Krawczyk P,Wojas-Krawczyk K,Sagan D,Milanowski J,Roliński J

更新日期：2008-01-01 00:00:00

abstract：:Propionibacterium acnes (P. acnes) has been implicated in the pathogenesis of acne vulgaris which is the most common cutaneous disorder. It has a proinflammatory activity and takes part in immune reactions modulating the Th1/Th2 cellular response. The exposure of dendritic cells (DCs) to whole bacteria, their componen...

journal_title：Folia histochemica et cytobiologica

authors： Michalak-Stoma A,Tabarkiewicz J,Olender A,Juszkiewicz-Borowiec M,Stoma F,Pietrzak A,Pozarowski P,Bartkowiak-Emeryk M

更新日期：2008-01-01 00:00:00

abstract：:STAT3 upregulates expression of HIF-1 induced EPO. Receptor EPOR was reported to activate STAT3. Our study was aimed at demonstration of tissue immunoreactivities of those proteins and determination of their relationships in reference to clinicopathological variables of breast cancers. We detected STAT3, HIF-1alpha, E...

journal_title：Folia histochemica et cytobiologica

authors： Wincewicz A,Sulkowska M,Koda M,Leśniewicz T,Kanczuga-Koda L,Sulkowski S

更新日期：2007-01-01 00:00:00

abstract：:Sperm genomic integrity and ultrastructural features of ejaculated spermatozoa contributing to the assessment of gamete fertility potential in patients with asthenozoospermia are discussed. The proportion of TUNEL-positive cells was significantly higher in the semen of patients with low sperm motility (n=40; p<0.01) a...

journal_title：Folia histochemica et cytobiologica

authors： Piasecka M,Gaczarzewicz D,Laszczyńska M,Starczewski A,Brodowska A

更新日期：2007-01-01 00:00:00

abstract：:Uterine leiomyoma is the most common tumour in women with a reported incidence of 25-30%. The tumors are benign, composed of smooth muscle cells with variable amount of collagen - rich fibrous tissue. It is well established that accumulation of extracellular matrix in leiomyoma is key feature of tissue fibrosis. Howev...

journal_title：Folia histochemica et cytobiologica

authors： Zbucka M,Miltyk W,Bielawski T,Surazynski A,Palka J,Wolczynski S

更新日期：2007-01-01 00:00:00

abstract：:Fertilization involves a series of cellular interactions culminating in the fusion of gamete membranes, creating a zygote and then an embryo. During the process of human fertilization in vivo or in conventional in vitro fertilization (IVF), sperm must be capable of undergoing the acrosome reaction, binding to the zona...

journal_title：Folia histochemica et cytobiologica

authors： Depa-Martynów M,Kempisty B,Lianeri M,Jagodziński PP,Jedrzejczak P

更新日期：2007-01-01 00:00:00